homologymodeling相关论文
先天性心血管疾病是一类由于遗传、环境及妊娠期感染等多因素相互作用而导致的先天性疾病，但确切的病因迄今尚不清楚。随着研究的逐......
Mechanism of Action of the Benzimidazole Fungicide on Fusarium graminearum: Interfering with Polymer
Tubulins are the proposed target of clinically relevant anticancer drug,anthelmintic,and fungicide....
Heterologous Expression and Homology Modelling of Sterol 14α-demethylase of Fusarium graminearum and
Fusarium graminearum is the main pathogen of Fusarium Head Blight (FHB),a worldwide plant disease and one of the major w......
Breast cancer(BC)is a molecularly heterogeneous disease still remaining a leading cause of women death in many countries......
In Silico Prediction of Binding Modes between Glucagon-Like Peptide-1 Receptor and Its Endogenous Ag
Diabetes,as a chronic metabolic disorder,has become the third major disease threatening the health of human being,and ty......
Background: Glycine receptor (GlyR) is member of ligand-gated ion channels that are also referred to as the Cys-loop rec......
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The Ras/Raf/MEK/ERK cascade is a pivotal signaling pathway activated by multiple extracellular stimuli and transmits sig......
Identification of pharmacophore model,synthesis and biological evaluation of N-contained chalcones f
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Heparin is an animal tissue extract that is widely used as an anticoagulant drug with more than 100 tons produced annual......
SM02-P22:Discovery of novel Kv1.5 potassium channel blockers using structure-based drug design strat
During recent years, Atrial Fibrillation (AF) is emerging as a major public health problem among the aging population.Th......
Binding Mode of Activators and Human Uncoupling Protein 1:A Combined Ligand-and Receptor-based Appro
Uncoupling protein 1(UCP1)plays an important role in promoting brown adipose tissue formation and strengthening function......
Homology modeling has been applied to fill in the gap in experimental G protein-coupled receptors structure determinatio......
Cytochrome P450(CYP)3A7 plays a crucial role in die biotransformation of the metabolized endogenous and exogenous steroi......
Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study
Gamma-aminobutyric type A receptor (GABAAR) is a member of the Cys-loop family of pentameric ligand gated ion channels (......
Molecular Modeling and MM-PBSA Free Energy Analysis of Endo-1,4-β-Xylanase from Ruminococcus albus 8
Endo-1,4-β-xylanase (EC 3.2.1.8) is the enzyme from Ruminococcus albus 8 (R.albus 8) (Xyn10A), and catalyzes the degrad......
The α1β2γ2 gamma-aminobutyric type A receptor (GABAAR) is one of the most widely expressed GABAAR sub-types in the ma......
The organophosphorous hydrolase (PTE) from Brevundimonas diminuta is capable of degrading extremely toxic organophosphor......
cholestenone 5alpha-reductase of Human,encoded in the gene SRD5A,is an important key enzyme in the biosynthetic pathway ......
Integrating Pharmacophore into Membrane Molecular DynamicsSimulations to Improve Homology Modeling o
Homology modeling has been applied to fill in the gap in experimental G protein-coupledreceptors(GPCRs)structure det......
β-Mannanase has been widely used in industries such as food and feed processing and thus has been a target enzyme f......
Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine b
N-acetyl glutamate kinase(NAGK)is a key enzyme in the synthesis of L-arginine,and L-arginine-sensitive NAGK typicall......
Cytochrome P450 (CYP) 3A7 plays a crucial role in the biotransformation of the metabolized endogenous and exogenous ......
Insights from investigating the interaction of oseltamivir (Tamiflu)with neuraminidase of the 2009 H
The neuraminidase (NA) of influenza virus is the target of anti-flu drugs oseltamivir and zanamivir.Clinical practic......
Identification of a Flavonoid glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants(
Flavonol glycosides,often converted from aglycones,a process catalyzed by UDP-glycosyltransferases(UGTs),play an imp......
The site-directed and saturation mutagenesis methods are very important to probe the structure-function relationship for......
As a pivotal signal pathway,the Ras/Raf/MEK/ERK cascade can be activated by multiple extracellular stimuli and can trans......
